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Abstract
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Long non-coding RNAs are driver to maintain the chromatin active regions at divergent transcriptional units Understanding of the diverse role of the human long non-coding RNAs (lncRNAs) is a considerable emerging field in development and disease (1). Download file PDF Download file. Chromatin deregulation is an emerging hallmark of cancer. A subset of these and additional pro-metastatic drivers (e.g. POU3F2, SOX9 and PDGFRA) as well as. Discovery of novel candidate drivers may unlock pathways to future medicines. Data download instructions and code to reproduce this work are available at GitHub under ‘edcurry/PRAD-compartments’. Keywords: Prostate cancer, Epigenetics, Transcriptional regulation, Chromatin compartments. Correspondence: e.curry@imperial.ac.uk. SIX2 (SIX homeobox 2)–positive nephron progenitor cells (NPCs) give rise to all epithelial cell types of the nephron, the filtering unit of the kidney. NPCs have a limited lifespan and are depleted near the time of birth. Epigenetic factors are implicated in the maintenance of organ-restricted progenitors such as NPCs, but the chromatin-based mechanisms are incompletely understood.
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